The CBD-IC Randomized Controlled Trial: Evaluation of Hemp Cannabidiol SuppositoRies for Pain and Urinary SymptOms in INterstitial Cystitis (CHRONIC) (CHRONIC) This study seeks to exploit bladder During sex, the abdominal pain that Interstitial Cystitis generates may be almost unbearable – however, many patients have reported significant improvement in their IC symptoms by using CBD.
The CBD-IC Randomized Controlled Trial: Evaluation of Hemp Cannabidiol SuppositoRies for Pain and Urinary SymptOms in INterstitial Cystitis (CHRONIC) (CHRONIC)
This study seeks to exploit bladder cannabidiol receptors as a therapeutic drug target by conducting a double-masked, placebo-controlled randomized trial evaluating the effects of vaginal hemp cannabidiol (CBD) suppositories on lower urinary tract symptoms (LUTS), pain severity, and sexual function.
|Condition or disease||Intervention/treatment||Phase|
|Interstitial Cystitis Bladder Pain Syndrome||Drug: Cannabidiol vaginal suppository Drug: Placebo vaginal suppository||Phase 1|
Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a chronic inflammatory disease with an insidious course and is detrimental weight to women’s quality of life, sexual function, and general health. IC/BPS affects nearly 1.2 million women in the United States and although there are currently six lines of treatment, they lack high level evidence and sufficient efficacy. New therapies are in high demand. As the cannabis industry gains popularity in medicine, research has revealed prevalent expression of cannabinoid receptors in bladder detrusor muscle and urothelium suggesting a novel drug target for IC/BPS. This study seeks to exploit this target by conducting a double-masked, placebo-controlled randomized trial evaluating the effects of vaginal hemp cannabidiol (CBD) suppositories on lower urinary tract symptoms (LUTS), pain severity, and sexual function. Women with diagnosed IC/BPS will be randomized to treatment with a placebo vaginal suppository or a hemp CBD vaginal suppository. We will monitor changes in their LUTS, pain, and sexual function using validated questionnaires. Our goal is to evaluate whether CBD is an effective, low-risk and less invasive treatment option for IC/BPS. Attainment of this goal would demonstrate a potential novel use for CBD in our Urogynecology patient population.
Best Lube for Interstitial Cystitis
During sex, the abdominal pain that Interstitial Cystitis generates may be almost unbearable. However, many patients have reported significant improvement in their IC symptoms by using CBD. For this reason, this article will discuss the best CBD lube for Interstitial Cystitis.
What Is CBD?
CBD is short for cannabidiol, the second most common active ingredient of cannabis after Tetrahydrocannabinol (THC). Unlike THC, CBD doesn’t cause psychoactive effects.
Marijuana is the name used for strains of cannabis that have more than 0.3% of THC. Hemp, while low in THC, is comparatively high in CBD. We can generally define hemp as being from the Cannabis sativa strain and having a THC content of less than 0.3%.
CBD does not induce the same feelings of ‘highness’ that people experience when they use marijuana. Furthermore, the World Health Organization reports that CBD doesn’t show any evidence of dependence to date. CBD may be present in vaping fluids, capsules, chocolate products, oils, and lubricants CBD lube can help reduce feelings of discomfort and improve your sexual life.
What Is The Best Lube For Interstitial Cystitis?
Sexologist and author Dr. Sadie Allison, and CBD scientist John Renko, B.S.E. created GoLove, a formulated lubricant made specifically for enhanced sexual health and wellness.
GoLove CBD Lube helps relax pelvic floor muscles and reduces any discomfort from inflammation, including discomfort caused by IC. Plus, GoLove creates a full-body calming sensation that helps relieve tension and sexual anxiety so that you can be more at peace during intimate moments.
Why is GoLove such a great lube for Interstitial Cystitis? Since it was created by doctors, GoLove has extra attention to detail when it comes to health.
- GoLove is water-based, ideal for lubrication and friendly with the lining of the vagina, and contains 200mg of organic CBD, a concentration high enough to be safe and effective. GoLove contains no THC.
- GoLove is research-based and naturally manufactured with body-safe ingredients
- GoLove is hypoallergenic, pH-balanced, and latex-safe so that anyone can use it.
- GoLove is lab-certified and dermatologist-tested. You can find the certification here .
Why Does CBD Help Interstitial Cystitis?
Endocannabinoids are molecules made by the body regardless of whether or not we use cannabis. They are essential in regulating processes like appetite and digestion, metabolism, pain, sleep, stress, reproduction, and fertility.
Some hopeful findings say that cannabinoid receptors are present in the lower urinary tract , which means the bladder walls line up with cannabinoid receptors. So, if systemic cannabinoids affect the lower urinary tract, they may become clinically useful.
THC binds to cannabinoid receptors, but CBD doesn’t. This fact leaves scientists somewhat mystified as to how exactly CBD exerts its effects. Still, it might either prevent your own body’s endocannabinoids from being broken down or improve the receptors’ ability to bind to them. It is also possible that CBD attaches to another type of receptor that is still unknown.
Is There Any Risk To Using CBD Lube?
Though CBD can have a few rare side effects like nausea, fatigue, and irritability, the biggest concern is that it is a supplement, and the FDA does not regulate it. There are a few precautions that can help make sure you’re getting a decent product. First, find out where the hemp was grown and whether it was organically grown. Hemp grown organically in the United States is best because there are stringent regulations in place to qualify as an organic product.
Next, look for a company that grows and extracts its hemp and provides test results from a state-certified testing facility either openly or upon request. Check the inactive ingredients as well.
Look for companies with contact information that is easy to find and lists where their hemp comes from and how it’s grown. Try calling and see if you get through or, at the very least, send an email and see if you can interact with a natural person. For Golove, you can get in contact here .
Is CBD Legal?
The legality factor is how much THC is in the CBD; if the product has less than 0.03 percent THC, it can legally be bought online and shipped right to your door.
Legality is a big question since CBD can come from marijuana, which isn’t legal in all states. But at the end of 2015, the FDA lowered its requirements to allow researchers to do more research on CBD. Its legality can also depend on whether the CBD comes from the hemp plant or the marijuana plant. Hemp plant derivatives are legal, but marijuana plant derivatives aren’t legal everywhere. Each of the 50 states in the United States now has unique laws regarding the legal status of CBD.