Can I Give My Dog Rimadyl And CBD Oil

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What many people don’t know is that dog CBD oil can interact with other medications by either enhancing the effect, or by interfering with the metabolism of some. Can Dog CBD interact with other medications that they're taking? Will it have a negative impact or create a great combo for our dog's health?

Can my Dog take CBD Oil While Taking Other Medications?

With the pet CBD market industry exploding globally, it’s no surprise that we need to look out for any drug interactions. What many people don’t know is that dog CBD oil can interact with other medications by either enhancing the effect, or by interfering with the metabolism of some.

In this blog, we’ll discuss why it’s important to consult with your veterinarian first before using CBD pet products.

Not only is this important so that you can get a proper diagnosis for a medical condition, but your veterinarian will be able to discuss any possible side effects if CBD is used together with other pet meds.

Here’s what you need to know to fully protect your pet, and to make sure that there are no drug interactions.

CBD can alter the way your dog processes certain medications

Yes, although cannabidiol (CBD) is a natural supplement that is beneficial for numerous health conditions in pets, as well as for chronic pain, insomnia, depression , and anxiety, CBD does have the potential to interact with certain medications.

CBD is derived from the hemp plant, yet it can also come from the marijuana plant. CBD hardly ever contains delta-9-tetrahydrocannabinol (THC), which is the compound that gives marijuana its “high” effect. High-quality CBD is non-toxic and considered safe for pets and humans alike.

There are almost no side-effects, apart from those coming from a low-quality CBD oil that may contain contaminants. It’s always best to look out for the compromised quality of some CBD oils.

You’ll need to discuss with your veterinarian all supplements, over-the-counter meds and prescription meds that your pet may be taking. Today research continues to demonstrate how effective CBD oil is for pets, yet one still needs to examine how it can interfere with the metabolism of pet meds and other supplements.

Benefits of CBD Oil for Dogs

Cannabidiol (CBD) extract is quickly gaining popularity as a natural alternative for managing pain, inflammation, and a variety of medical conditions, including epilepsy. However, recent reports have called into question the safety of CBD when used together with other pet meds. It’s also good to note that using a compromised quality or low-quality CBD oil raises the risk of side effects.

A recent 2019 study by the University of Korea, demonstrates that the CBD anti-cancer protein shows potential in killing tumor cells. The researchers tested the synergistic effect of CBD with a cancer destroying protein called TRAIL. (TNF related apoptosis- inducing ligand.)

The study concluded that TRAIL and CBD created apoptosis separately in colorectal cancer cells. The researchers also found that together, both reduced cancer cells a lot. “ To the best of our knowledge,” they wrote, “this is the first report that cannabidiol induces significant TRAIL-induced apoptosis of colorectal cancer cells,” noting that earlier reports suggested that a different protein response was responsible for cancer-cell death.” via MDPI Journals.

FDA & CBD

The FDA has also tested the chemical content of cannabinoid compounds in some of the products, and many were found to not contain the levels of CBD they claimed to have. We have also heard reports of CBD potentially containing contaminants (e.g., pesticides, heavy metals); we are looking into this.

Some cannabis products are also being marketed as pet food and health products for animals. The FDA has not approved cannabis for any use in animals and recommends pet owners talk with their veterinarians about appropriate treatment options for their pets.” via FDA, 2019.

Blood Pressure and CBD Oil

High doses of CBD oil may potentially drop blood pressure resulting in lightheadedness and possibly dizziness in people. It’s always best to consult with your veterinarian for the best advice prior to purchasing a CBD product. That said, the positive side of CBD oil use is that it may be good for patients with high blood pressure. CBD together with regular exercise and a healthy diet help to regulate hypertension.

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A 2017 study by Dr. K Jadoon on CBD and its effects on blood pressure demonstrated the following:

The study concludes that “acute administration of CBD reduces resting BP and the BP increases stress in humans, associated with increased HR. These hemodynamic changes should be considered for people taking CBD. Further research is required to establish whether CBD has a role in the treatment of cardiovascular disorders.”

CBD Oil Interacts with Anti-Seizure Meds

A study researching CBD interactions with seizure meds in people added that “ Because all of the participants are also taking other seizure drugs while they are receiving the investigational therapy, investigators checked the blood levels of their other seizure drugs to see if they changed. “With any new potential seizure medication, it is important to know if drug interactions exist and if there are labs that should be monitored while taking a specific medication,” said lead author Tyler Gaston, MD,” via Science Daily.

Dr. Gaston and her colleagues found that there were significant changes in levels of the drugs clobazam (and its active metabolite N-desmethylclobazam), topiramate, and rufinamide in both adults and children, and zonisamide and eslicarbazepine in adults only.

Except for clobazam/desmethylclobazam, however, the drug levels did not change outside of the normally accepted range. In addition, adult participants in the study taking clobazam reported sedation more frequently.

Additionally, when seizure patients were using valproate, they added that “Tests also showed that participants taking valproate and CBD had higher ALT and AST (liver function tests) compared with participants not taking valproate.

Very high ALT and AST indicate abnormal liver function, but significant ALT and AST elevation occurred only in a small number of participants (4 children and 1 adult), and the levels returned to normal after discontinuation of valproate and CBD.”

The study concludes that “The findings emphasize the importance of monitoring blood levels of antiepileptic drugs as well as liver function during treatment with CBD. “

A perception exists that since CBD is plant based, that it is natural and safe; and while this may be mostly true, our study shows that CBD, just like other antiepileptic drugs, has interactions with other seizure drugs that patients and providers need to be aware of,” said Dr. Gaston.”

Cytochrome P450

CBD as a natural supplement does not cause a “high” in pets, but may cause a reaction when used together with anti-seizure meds. Cannabinoids have been shown to inhibit cytochrome P450 enzymes by using up these enzymes, and by inhibiting how other enzymes work.

When cannabidiol oil is consumed by dogs in large amounts, a large group of enzymes may be altered in the same way that grapefruit alters enzymes.

Most pet meds are metabolized in the liver via certain enzymes that are made in it. CBD works in the same way that grapefruit does, and may use up all the enzymes and also alter the effectiveness of pet meds.

NSAIDs and Corticosteroids

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are a class of drugs commonly used to control pain and inflammation in dogs. NSAIDs help many dogs lead a life that is more comfortable for them, but what about interactions with CBD oil? CBD oil has the potential to make pet meds less effective.

That said, pet parents should take every precaution to ensure that there are no interactions with any of their pet meds or supplements, and even NSAID’s, corticosteroids, pet herbal supplements and vitamins. The potential for adverse reactions will also depend on the body chemistry of your pet and the dose of the prescription or supplement.

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Administer CBD oil 2 hours before or 2 hours after giving pet meds or supplements.

NSAID’S include the following:

  • Rimadyl
  • Metacam,
  • Deramaxx,
  • Etogesic

Meds like Gabapentin when taken together with CBD can cause lethargy in pets. It’s important to discuss CBD use with your veterinarian prior to administering.

Common corticosteroids include the following:

  • Prednisone
  • Triamcinolone,
  • Dexamethasone,

The most common symptoms when using these are gastrointestinal issues like lack of appetite, vomiting, diarrhea, and even ulcers. We all know that pets cannot take both NSAID’s and corticosteroids at the same time, but what about cannabidiol oil and NSAID’s and corticosteroids?

CBD oil can also enhance the effectiveness of certain drugs and one may be able to lower the dose of pet meds or therapy when using CBD oil. Pet meds that are used for pain relief need to be administered carefully when using them together with CBD oil.

CBD for Dogs And Its Interaction With Other Medication

Dog CBD interaction is a reaction between CBD and the other drug your dog is taking. These days, more and more people are now including CBD in their dog’s everyday life.

However, is CBD oil interacting with other medications okay? Below, we’ll tackle if dog CBD can have a negative side effect on dogs taking other medication.

The benefits of CBD are great and are a safe supplement in general. However, will it complement other medications? Well, it depends on the drug they are taking.

Dog CBD Interaction with Medications

CBD and Rimadyl interaction for dogs

Rimadyl is a Non-Steroidal Anti-Inflammatory Drug or NSAID. NSAIDs are a class of drugs prescribed to manage pain or reduce inflammation in dogs.

Studies have shown that it doesn’t have any drug interaction with CBD. But that doesn’t mean it will not exist in the future.

In this case, dog CBD interaction will depend on the dog’s body chemistry and the dosage of CBD or Rimadyl. CBD can help maintain the dog’s well-being and balance with proper dosage.

CBD and Melatonin Interaction for Dogs

What even is Melatonin? Melatonin is a hormone released by the pineal gland in the brain that helps regulate the dog’s sleep and even waking up.

The powerful combination of CBD and Melatonin helps the dog’s wellness support. Some of the benefits found in CBD and Melatonin provide the same effects for your dogs.

CBD is known for its calming properties. Melatonin, on the other hand, provides comfort and restful sleep. This combo can work together to help maintain the dog’s well-being and proper rest.

CBD and Benadryl for Dogs

Benadryl is an antihistamine that is given to dogs that experience allergy symptoms.

It is usually prescribed by vets to treat environmental allergies or allergies caused by insect bites or stings.

It works by blocking the histamine (H-1) activity that causes allergic symptoms on a dog’s body. There is no known interaction between Benadryl and CBD.

But there can still be risks. CBD and Benadryl are both metabolized through the cytochrome P450 Enzyme System. This can increase the chances of doubling the side effects of both CBD and Benadryl.

It can potentially cause severe drowsiness or fatigue. We suggest checking with your vet before combining these two.

CBD And Glucosamine Interactions

CBD and Glucosamine can be an excellent combination for a dog that suffers from joint problems like arthritis or joint pain in general.

Glucosamine is one of the most popular over-the-counter arthritis medicines. It is usually given to manage pain on the joints caused by hip dysplasia. Glucosamine can also help with the treatment of spinal disc injury.

With the two-punch combo of CBD and Glucosamine, it can help reduce pain and inflammation from your dog’s joints.

CBD and Prednisone for Dogs

Dog CBD interaction with Prednisone is not recommended for dogs. Prednisone is a prescription steroid used to reduce inflammations, treat allergy symptoms, arthritis, and more.

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CBD and Prednisone together are not recommended for dogs as they can increase the side effects of both. They are both inhibitors of the CYP450 Enzyme System.

If you’re planning to give CBD oil to your dogs while they are on different medications, it is best to consult with your vet in these situations.

CBD and Meloxicam Lethal Combo for Dogs

Meloxicam, likewise Rimadyl, is a Non-Steroidal Anti-Inflammatory Drug or NSAID. Meloxicam is prescribed as a pain killer that helps ease inflammation in dogs.

There is a chance that taking NSAIDs with CBD can increase the effects of these pain killers. It all comes down to proper dosage on meds and supplements.

You, as the owner, have the responsibility to research, talk to your vet, and monitor your dogs when taking the CBD route in addition to meloxicam.

Commonly Asked Questions

Will Benadryl help with Dog Anxiety?

Well, yes and no. You have to identify what kind or cause of their anxiety.

Benadryl can help reduce dog anxiety symptoms. It is also used as a sedative to help dogs during fireworks, thunderstorms, or traveling. But overall, Benadryl is not helpful for dogs struggling with anxiety or phobias.

It has high efficiency in helping dogs with motion sickness. However, it can have opposite side effects on rare occasions where your dogs will be hyperactive rather than sedated.

Proper Dosage of Benadryl for Dogs

Giving dogs about 2-4mg of Benadryl for every kilogram of body weight is good. However, it is still best to consult with your vet and wait for their approval before you take action.

Administering the correct dosage of Benadryl for dog anxiety is crucial. The wrong amount can have serious consequences.

How often do I give CBD oil to my dog?

This all depends on the dog’s condition. Some dogs can benefit from daily doses, and others can not.

For example, dogs suffering from arthritis or seizures can benefit from a daily or twice a day dose of CBD between 2-8mg/kg or lower. An interval of eight to twelve hours is advised when CBD twice a day.

A good rule of thumb when administering CBD oil for your dog is 1-5mg CBD for every 10 pounds of their body weight.

What happens if your dog takes too much CBD?

CBD is a non-toxic and non-psychoactive compound meaning it will not get ‘high’. However, when taken too much intense, concentrated CBD, potential side effects can develop.

A few of these symptoms are lethargy (lack of energy), vomiting, drowsiness, urinary incontinence, and hypersensitivity.

Dog CBD Interaction with other Medication Summary

Due to a lack of research, there are still many things that we don’t yet know about the world of CBD, not just for humans but also for dogs. But we cannot deny the great benefits of CBD for dogs.

When giving CBD to our dogs, there are still many things to consider. We must focus not only on the correct dosage but also on other medications that they need.

Studies showed that CBD has no known interaction with medications, but it doesn’t mean it will stay like that. Dog CBD interaction will depend on the dog, CBD, and the medicine.

Our vets usually prescribe these medicines. It is still the best choice to consult with your vet in CBD drug interactions.

Since the FDA doesn’t regulate CBD products yet, most US Veterinary and Pharmacy boards are advised to avoid prescribing or discussing CBD until further notice.

Always remember that you are the one in control when it comes to CBD oil drug interactions.

You have the power to help your dogs maintain a well-balanced life. Research, consult with your vet, and monitor.

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