Can I Mix CBD Oil With Melatonin


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Melatonin and CBD oil can help reset your sleep/wake cycle. Here's a detailed guide on how to take CBD oil and melatonin safely! One type of sleep aid gaining notoriety as of late are CBD products with added melatonin. Melatonin is a naturally occurring hormone that helps our bodies fall asleep. But is it safe to combine melatonin with CBD oil?

CBD Oil vs Melatonin

It may be time to quit taking Ambien when you start receiving those random Amazon packages.

A chainsaw, a ski mask, and latex gloves? Who ordered these packages? You did, apparently.

Sedatives can have unwanted side effects like Ambien’s alarming Amazon-binging blackouts. Prescription sleep aids can also be addictive or unsafe to their users and others (see chainsaw..).

We want to propose a more natural route when it comes to sleep aids. In this article, we will introduce both melatonin and CBD oil as supplements that can help reset your sleep/wake cycle safely.

Melatonin for Sleep

Melatonin is a hormone that is naturally produced in the pineal gland of the brain and is released in response to darkness. Conversely, it is suppressed by light. By this mechanism, it helps control the sleep-wake cycle we know as the circadian rhythm.

How Melatonin Works

The amount of melatonin you produce influences wakefulness during the day and sleepiness when the sun goes down. Typically you will get a bigger hit of melatonin in the evening, the biggest quantities peaking between 11 PM and 3 AM.

The darkness triggers the activation of melatonin and its receptors, called the MT1 and MT2 receptors. This keeps you sleeping like a baby.

But when the sun is out, there isn’t much melatonin in the bloodstream. Instead, we experience more of an opposite effect from other hormones like cortisol. This stress hormone is secreted when the morning light comes. That I’m-going-to-have-a-complete-mental-breakdown-today feeling is our body’s way of waking us up, getting us ready for the day. Thanks hormones.

But when you aren’t getting enough melatonin, you may have issues sleeping. Some things that interfere with our natural melatonin production are:

  • Aging: Like a lot of things that decline as we age the production of melatonin tends to decrease very quickly. Especially after we turn 60, our pineal glands become more calcified and there is less sensitivity in the melatonin receptors.
  • Artificial light: Since the body decreases melatonin when we are exposed to light, even artificial light is not exempt. And since we are commonly around screens and LED bulbs that give off a lot of blue light, this can confuse our body into wanting to stay awake.

Uses of Melatonin

Using melatonin as a supplement can help reset an unbalanced sleep/wake cycle. Synthetic melatonin can also activate melatonin receptors in the brain. In what is called melatonin replacement therapy, synthetic melatonin has the following uses:

  • Treating insomnia
  • Alleviating jet lag
  • Improving sleep quality
  • Wake up less
  • Reduces sleep latency
  • Balancing sleep/wake cycle of blind people
  • Shift work

Melatonin Caveats

Before adopting melatonin into your sleep routine, there are a few things to be aware of.

Caveat #1: Avoid bright or blue light before bedtime

If you take melatonin before your targeted bedtime, and you expose yourself to bright or blue light, you are negating the effects of the supplement. Sorry Instagram scrollers. The light from your phone is confusing your body and sending mixed messages.

Try to avoid watching Vanderpump Rules or blasting through your Instagram right before lights out. We like to turn our screens off 2 to 3 hours before bedtime.

The light in your room can also affect sleep. The more warm and yellow your lamplight, the more likely your brain will think it’s sleep time. Avoid LED lighting, which has more of a bluish hue that keeps you awake.

Caveat #2: Don’t take it during the day

If you take melatonin in the daytime, or closer to daylight hours (like 3 to 4 AM), you may feel drowsy and groggy the next morning. Your circadian rhythm may be thrown off as a result.

The only caveat to this caveat is shift workers and the jet-lagged. Taking melatonin during the day can be helpful for those night shift workers who have to sleep during the day. It can also minimize jet-lag-related downtime on your family vacation to Europe, allowing you more time to climb the Eiffel Tower and relax with the fam in French cafes.

Caveat #3: It is not a sleeping pill

Melatonin is meant for short-term use only. At this time, there are no long-term studies for melatonin use. This supplement is simply meant to reset the sleep/wake cycle, not to be used as a nightly sleeping pill. Once you have enough melatonin in your body, you should just use it incrementally as needed.

Melatonin Side Effects and Interactions

When it comes to taking melatonin, less is more. Believe it or not, you can overdose on melatonin. Since it is a natural hormone that can become out of balance, it is possible to tip that balance to where you have taken too much. An overdose can daytime sleepiness, nightmares, vivid dreams, or any of the following effects:

  • Headache
  • Dizziness
  • Nausea
  • Drowsiness
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Less common side effects include:

  • Short-lasting depression
  • Mild tremor
  • Mild anxiety
  • Joint pain
  • Diarrhea
  • Cramps
  • Irritability
  • Reduced alertness
  • Confusion or disorientation
  • Abnormally low blood pressure (hypotension)

Taking melatonin may have some negative interactions and other substances. Some of these interactions include:

  • Anticoagulants
  • Immunosuppressants
  • Diabetes medications
  • Birth control pills
  • Other sleep medications like Klonipin, Ativan, Ambien, and Valium
  • Alcohol

Although melatonin can help you fall asleep easier when used correctly, it may not be the final solution for you. Sure, it could reset the problem temporarily, but the underlying issue may come back, causing you more sleepless nights.

Temporary relief from melatonin may indicate that you have an underlying sleep disorder, caused by things like chronic pain or sleep apnea.

But what are the most common issues that cause insomnia? The answer: stress, anxiety, or depression.

If you are a cortisol junkie like the rest of us, you may have trouble falling asleep, staying asleep, and getting restful sleep. Hours are spent flipping in the bed like a pancake, worrying about your to-do list or every embarrassing thing you did in high school.

Alleviating stress, anxiety, and depression may be a better method of addressing your underlying sleep issues.

Here are a few suggestions to help alleviate these issues:

  • Cognitive-behavioral therapy (CBT)
  • Meditation
  • Limit alcohol and caffeine
  • Exercise
  • Breathing exercises
  • Diet change
  • CBD oil

CBD Oil for Sleep

Cannabidiol (CBD) comes from the cannabis plant and is usually served in the form of hemp extracts mixed with a carrier oil. CBD has been shown to have positive benefits on stress, anxiety , and depression . The relief can also translate to better sleep . These benefits of CBD not only help you catch more ZZz’s, but it can also benefit other health conditions and overall wellness.

How CBD Works

Like melatonin, CBD influences G-protein coupled receptors in our body. CBD interacts with what is known as cannabinoid receptors of our endocannabinoid system (ECS). CB1 and CB2 receptors regulate things like mood, sleep, appetite, memory, and more.

Sleep patterns can be affected by our high cortisol levels. Our stress response is tended to by endocannabinoids 2-AG and anandamide (AEA). Though these two are working on the same stress-inhibition team, they have different functions.

When stress is elevated, 2-AG tries to terminate the threat by blocking the CB1 receptor . This just makes you more stressed and anxious by trying to get rid of the problem! On the other hand, anandamide’s job is to nullify the stress or pain. With the help of CBD, anandamide levels (2-AGs enemy) are increased, which promotes fear extinction and can reduce cortisol . And when you are less stressed, you get better sleep !

Best CBD Oil for Sleep

Our customers love our Nightcap CBD: CBN Sleep Drops. This full-spectrum CBD tincture (includes THC unlike broad-spectrum oil) has the whole gang of cannabinoids and terpenes, as well as soothing botanicals to get you more restful sleep. Here is just a summary of the ZZzz-beneficial compounds in Nightcap:

CBD Side Effects and Interactions

CBD is generally well-tolerated. Though not common, side effects of CBD may include:

  • Dry mouth
  • Diarrhea
  • Reduced appetite
  • Drowsiness and fatigue

Talk to your doctor before taking cannabidiol. You may experience increased side effects if CBD interacts with:

  • Antidepressants like Prozac
  • Certain heart medications
  • Antipsychotics and benzodiazepines
  • Antibiotics like erythromycin and clarithromycin

As another word of warning, be aware of unreliable CBD products that are flooding the market. Since ours is a relatively new industry, there are very few CBD products that are regulated by the FDA.

As a result, you will find many CBD gummies, tinctures, vapes, and topicals out there making false claims and purity and doses. Stick with high-quality, third-party tested CBD products from Juna World.

Can You Take CBD Oil & Melatonin Together Safely?

Yes, you can take CBD oil and melatonin together safely. We have mentioned how both CBD and melatonin work. They both influence G-protein coupled receptors, which have similar structures and processes in our bodies. This suggests that taking CBD oil with melatonin may help you get a good night’s sleep.

When taking CBD and melatonin together, this can be a powerful duo for getting you back into your body’s natural sleep rhythm. As you can see, they are both considered safe. Both have been proven to affect sleep. But when taken together , they may be even more effective.

Since they work in similar ways, their processes may actually complement each other. While melatonin works to reverse the effects of disrupted hormones, CBD can help your overall sleep quality by minimizing anxiety and stress.

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And best of all, CBD and melatonin:

  • Don’t cause hangovers
  • Have no withdrawal symptoms
  • Have no serious side effects

How to Take CBD & Melatonin Together

Although these two are both considered safe to take, you need to make sure you don’t overdo it. Finding the right balance is essential when it comes to sleep aids.

As always, we recommend starting with low doses to get your body acclimated and to recognize the incremental changes that are caused by these supplements. As you get comfortable, then you can slowly up your doses.

Mixing Cannabidiol (CBD) with Melatonin: What We Know

One type of sleep aid gaining notoriety as of late are CBD products with added melatonin. Melatonin is a naturally occurring hormone that helps our bodies fall asleep. But is it safe to combine melatonin with CBD oil?

Alexa Peters is a Seattle-based freelance writer and editor with a specialty in arts & culture, wellness, and lifestyle journalism, as well as content writing. My cannabis and CBD-focused work has appeared in Leafly, CannabisMD, Healthline, Green Valley Nation, and many other publications.

Here are our key findings:

  • CBD research into sleep is still preliminary, but has shown promise in some people for treating insomnia
  • Melatonin can help regulate sleep and wake cycles in some people
  • Mixing Melatonin and CBD is generally safe and several combination products are available
  • Certain populations, including pregnant women, those with seizure disorders, diabetes, or anyone taking blood pressure medications are advised to consult their doctors before using melatonin

What We Know About Cannabidiol (CBD) and Sleep

50 to 70 million Americans suffer from chronic insomnia every year. That could be why the sleep aid market is estimated to be worth $162.5 billion by 2030.

Despite its retail popularity, the data available on CBD for sleep “ is in its infancy ,” according to researchers.

There is some information on the behavioral effects CBD can have, though. Authors of the aforementioned paper sought out to investigate CBD’s role on anxiety and sleep quality in 103 adult patients. They discovered that sleep scores improved for 66.7% of patients in the first month but fluctuated over time.

Another clinical trial comparing CBD with Nitrazepam, a benzodiazepine with hypnotic properties, found administration of doses of CBD 160 milligrams or higher significantly increased the duration of sleep . Other studies show that cortisol levels decrease with CBD administration at doses as high as up to 600 mg . The decrease in cortisol levels yielded a sedating effect for patients.

Another review of the literature on cannabinoids like CBD for sleep published in 2017 “suggests that cannabidiol (CBD) may have therapeutic potential for the treatment of insomnia” as well as showing promise for REM sleep behavior disorder and excessive daytime sleepiness.

While CBD’s exact mechanism of action is still unknown, the working theory behind how CBD works for sleep suggests its reduction in anxiety plays a part.

CBD can also impact sleep by helping our bodies’ endocannabinoid systems better maintain circadian rhythm. Circadian rhythm is the internal process by which our bodies regulate our sleep and wake cycles. Available data suggests endocannabinoid signalling is implicated in the circadian process , and if we know CBD impacts our endocannabinoid systems its possible CBD can , “…serve as a chronobiotic [an agent that can cause phase adjustment of the body clock] therapeutic compound for individuals with disrupted circadian function.”

In other words, if your body struggles to naturally wake and fall asleep every day, CBD may be able to help.

What We Know About Melatonin and Sleep

Melatonin is a naturally occurring hormone. Produced by the pineal gland at night, its primary function is to regulate circadian rhythms and help promote sleep.

Melatonin’s reputation catapulted it to becoming one of the most popular dietary supplements on the market today. It’s marketed as a sleep aid, but is the research there to support the idea?

Yes and no. A 2021 review examining the safety and efficacy of melatonin found that melatonin could advance the time of sleep onset—making you feel sleepy more quickly—but the effect was “modest and variable.”

“Most people’s bodies produce enough melatonin for sleep on their own,” explains sleep expert Luis F. Buenaver, director of the Behavioral Sleep Medicine Program at Johns Hopkins’ Department of Psychiatry and Behavioral Sciences. “However, there are steps you can take to make the most of your natural melatonin production.”

Buenaver recommends using melatonin supplements for a specific set of circumstances—on a short term basis for insomnia, overcoming jet lag or for those looking to fall asleep and wake up earlier.

Can I mix CBD and Melatonin?

Though there is little to no research into the long-term effects of combining cannabis and melatonin, the general consensus from brands and consumers who create CBD and melatonin products have found that, generally, yes, you can combine CBD and melatonin safely.

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That said, according to Leaf Report Medical Reviewer Eloise Theisen, MSN, AGPCNP-BC, melatonin should only be used for the short term and is not considered a long term solution to sleep issues.

“If you need help staying asleep rather than falling asleep, the addition of melatonin may not be necessary. Melatonin can cause a drugged, groggy effect in some and may not be necessary to add to a CBD regimen for sleep,” she said.

At Elevated Wellness , a CBD brand founded by health care professionals based in Austin, TX, their CBD-melatonin products are some of the brand’s top sellers. In using these products, the brand’s Marketing Manager Daniel Britt stresses the importance of understanding dosing is unique to each person.

“It’s not just about weight, which is what we first assume because of other pharmaceuticals,” says Britt. “It actually doesn’t have to do as much with weight as it does with body chemistry.”

Finding the right dose then, can take some trial and error. Going overboard on dosing can result in “hangovers” the next day, or feelings of immense grogginess that can accompany too much CBD or melatonin, says Britt. In fact, Thiesen adds, “CBD can be stimulating at low doses, so adding in melatonin may counteract that effect and make low-dose CBD more suitable for sleep.” So, you shouldn’t require a super high dose of CBD-melatonin product to see effects.

Thus, experts like Britt suggest a low and slow approach to trying CBD and melatonin—especially if you already know you’re very sensitive to CBD or melatonin’s effects. For instance, Elevated Wellness’ products suggested dose is 1 ml of the tincture under the tongue, but if you are concerned about how it might affect you—do half of that and increase from there based on how you feel.

Additionally, both Thiesen and Britt emphasize that if you have never taken CBD or melatonin before, it is best not to mix them until you have tried them separately to see how you respond to them individually.

“It may be wise to try CBD products without melatonin first to see how that works for you,” said Britt, adding that taking the two together may enhance the strength of the overall effect.

Thus, in the end, melatonin may not be necessary to add to a CBD regimen for sleep, Thiesen says.

How to find quality products containing CBD and Melatonin

In addition to taking a “low and slow” approach to dosing, it’s essential consumers ensure the efficacy and safety of their CBD/melatonin product by vetting its quality. Here’s how:

  • Ensure the safety and quality of your CBD/Melatonin product by checking out the companies’ reputation here at LeafReport’s Brand Reviews and/or by ascertaining if the company has been issued an FDA warning letter .
  • Look over the lab reports produced by the company. Here are some points to look for in the “ Certificate of Analysis ” or CoA.
  • Make certain that the lab used has a state license, is ISO accredited and that the CoA is signed and dated—this information is usually found on the last page and sometimes in a header or footer.
  • Make sure the product received a “passing grade” when it comes to the levels of heavy metals, pesticides, microbials, mycotoxins, residual solvents and debris.
  • Look for less than 0.3% THC in the product. This is the legal limit for THC in any CBD product. This is especially important for those concerned about drowsiness or other undesirable side effects of cannabis.

Elevated Wellness, for instance, third-party tests both their CBD and the melatonin that they use in their combination products, and they source all the extracts used in their products from pharmaceutically regulated labs to ensure the utmost quality of their products. They also third-party test for heavy metals, pesticides, microbials, mycotoxins, residual solvents and debris.

All of this information is readily available on their website, or through contacting their team for a CoA—and that’s the kind of transparency you want in whatever brand you’re purchasing your CBD/melatonin product from.

Safety of CBD and Melatonin

Certain populations, however, are not advised to use melatonin including pregnant women, those with seizure disorders, diabetes, or anyone taking birth control pills, blood thinners, or blood pressure medications. Some melatonin supplements can raise blood pressure levels in those taking certain medications.

This can be a risky interaction with CBD as a 2017 research study found taking CBD with antihypertensive medications may change blood concentrations of either substance. The same goes for taking CBD and blood thinners.

As such, at risk populations should speak to a healthcare professional before using products that contain CBD and melatonin.

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